Datar Cancer Genetics Announces break-through Innovative Ttreatment options for late-stage Cancer Patients

by Shrutee K/DNS

November 11, 2019: Datar Cancer Genetics Limited, a molecular genomics company based in Nashik, Maharashtra, India, has announced outcomes of their ‘Resilient’ study, which offers new hope for late-stage cancer patients. The study showed that in a majority of these patients (90.5%), further progression of cancer was halted, while a significant number of patients (43%) responded to the treatment, leading to a healthy decrease in the extent of their cancers.

The Trials

The trials, named RESILIENT, had patients with difficult cancers receiving treatment guidance based on the Exacta solution analysis. Under this trial, 143 patients started off being given the treatment, and 126 patients were evaluable as per the study criteria. In these patients, cancer had progressed following multiple treatment failures. All patients underwent PET-CT and brain MRI scans prior to the start of the treatment. At the end of the treatment too, they were made to undergo the same scans. In an encouraging sign, while no treatment-related mortalities or critical adverse events were reported in this study, a majority of these patients reported improvement in the quality of their lives, said the ISO15189 and College of American Pathologists (CAP)-accredited Company.

The unique approach adopted in the trial for determining the drugs that can be effective for cancer patients has been made possible through the Exacta analysis offered by Datar Cancer Genetics. It uses cutting-edge technologies that analyse the DNA, RNA, proteins and circulatory tumour cells of the patient. The Exacta analysis allows for the identification of critical features of cancer. And based on the established efficacy and safety profile, certain drugs or a combination of drugs thereof, are then indicated for treatment. The solution involves comprehensive in-depth tumour gene expression analysis, integration of millions of data points at the molecular level to reveal all possible targets for precision drugs, which in turn enables effective tumour burden monitoring, therapy response monitoring and detects early therapy failure or recurrence.

Responses

Dr Tim Crook, Medical Oncologist at the St. Luke’s Cancer Centre, Royal Surrey County Hospital, Guildford, UK, one of the authors of the study, said, “Patients in the United Kingdom and all over the world have much to gain from the outcome of this trial.”

According to Dr Vineet Datta, another of the authors, a unique feature of this approach and innovative technology is the selection of the most effective drug treatment combinations matched with drugs that offer the least toxicity. “The conventional ‘Standard of Care’ approach does not take into consideration the overall genetic architecture of a particular patient’s tumour, and consequently, the patient could suffer from failed therapies or aggressive relapse. Difficult cancers do not always need new treatments; rather an intelligent approach can yield treatment benefits with existing anti-cancer drugs.”

Treatment

One of the most formidable challenges faced by the cancer-treating community is to be able to achieve superior clinical outcomes for refractory late-stage solid cancers among patients who have not responded positively to multiple lines of clinical therapy. The reasons for this are many. For one, some cancers become resistant to various types of drugs. And once cancer turns drug-resistant, it poses serious clinical challenges, including there being virtually no lines of treatment available to tackle it, and the outcome moving towards palliative care.

In such a scenario, genetic tests serve diverse purposes, including screening and diagnosis of genetic diseases, prediction of drug responses and identifying targeted therapies to provide customized cancer care. With the benefits of genetic testing increasingly getting established, it is essential to make efforts to increase the level of access to genomic services for all who can benefit from this late-stage condition.

Link of the study published: https://doi.org/10.18632/oncotarget.27188

Cancer in India

According to the Indian Council of Medical Research (ICMR), India was home to 14 lakh cancer patients in 2016. And this number is increasing year after year. Breast cancer, cervical cancer, oral cancer, and lung cancer account for about 41 per cent of the nation’s cancer burden. Of this, breast cancer is the number one killer of women, and lung cancer the top killer of men in the country.

About Datar Cancer Genetics

Datar Cancer Genetics Limited (DCGL) is a molecular genetics facility established in 2013 as a Centre for Excellence in precision genetic analysis with an aim to meet and exceed globally recognized standards and to maximize customer satisfaction. DCGL is India’s most modern, fully integrated facility for molecular pathology, genetic analysis & tissue investigation, spread over more than 30000 sq. ft. It has focused largely on developing services that offer a greater insight into precision, customized and personalized medicine through its diverse ecosystem of innovative oncology solutions. It has a strong and competent team of over 180, comprising world-class scientists, researchers, specialist clinicians and data analysts and a fully integrated sequencing, bio-informatics and interpretation platforms, with access to international databases. DCGL is accredited by the International Standards Organisation (ISO 9001, 2015), National Accreditation Board for Laboratories (NABL) and the College of American Pathologists (CAP). It offers its solutions across 10 countries and in over 100 cities across India.